Selected Drugs Clear All
MultiCheck Results
- 4
Interactions
Avoid/Use Alternative |
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Cheratussin AC
(codeine/ guaifenesin) + Topamax
(topiramate) |
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Avoid/Use Alternativecodeine + topiramate avoid combo if antitussive use; otherwise, use alternative or monitor withdrawal sx, respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo with topiramate doses >200 mg/day may decr. codeine and active metabolite morphine levels, efficacy; may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (hepatic metabolism induced, may decr. production of active metabolite morphine; additive effects; antagonistic effects, codeine may decr. seizure threshold) |
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Cheratussin AC
(codeine/ guaifenesin) + Vasculera
(diosmiplex) |
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Avoid/Use Alternativecodeine + diosmin use alternative or monitor respiratory rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited, may incr. production of active metabolite morphine) |
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Monitor/Modify Tx |
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Cambia
(diclofenac potassium) + EstroGel
(estradiol transdermal) |
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Cambia
(diclofenac potassium) + Vasculera
(diosmiplex) |
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Monitor/Modify Txdiclofenac + diosmin monitor bleeding s/sx; use lowest effective diclofenac dose, shortest duration of concomitant tx: combo may incr. diclofenac levels, risk of GI or other bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited, additive effects) |
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Additional Considerations |
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topiramate
in Topamax
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beverages or products containing ethanol are contraindicated within 6h of topiramate extended-release (ER) capsules administration; combo may incr. topiramate release rate, levels, risk of adverse effects, decr. duration of efficacy |
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codeine
in Cheratussin AC
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consider prescribing an opioid overdose reversal agent, especially with concomitant CNS depressant use add MAO inhibitor to Interaction Check if recent (14 days) use |
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