Selected Drugs Clear All
MultiCheck Results
- 1
Interaction
Avoid/Use Alternative |
||
|
MS Contin
(morphine sulfate) + trazodone
(generic) |
||
Avoid/Use Alternativemorphine + trazodone use alternative or monitor respiratory rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. morphine levels, risk of profound CNS and respiratory depression, psychomotor impairment, serotonin syndrome, severe hypotension (including orthostasis, syncope), other adverse effects (P-gp-mediated transport inhibited, additive effects) |
||
Additional Considerations |
||
|
morphine
in MS Contin
|
||
|
consider prescribing an opioid overdose reversal agent, especially with concomitant CNS depressant use add MAO inhibitor to Interaction Check if recent (14 days) use avoid combo with beverages or products containing ethanol and some morphine extended-release (ER) capsules; combo may incr. morphine release rate, levels, risk of adverse effects, including life-threatening overdose, decr. duration of efficacy |
||
|
trazodone
|
||
|
add MAO inhibitor to Interaction Check if recent (14 days) use |
||