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Interaction Check

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Selected Drugs Clear All

  • remove Enskyce
    desogestrel/ ethinyl estradiol
  • remove ibuprofen/ famotidine
    generic
  • remove Isibloom
    desogestrel/ ethinyl estradiol
  • remove Junel Fe 24
    norethindrone/ ethinyl estradiol
  • remove Verquvo
    vericiguat
  • remove Wellbutrin SR
    bupropion hydrochloride

multicheck MultiCheck Results - 16 Interactions

Smiley face Smiley face

Avoid/Use Alternative

Smiley face Smiley face Enskyce (desogestrel/ ethinyl estradiol) + Isibloom (desogestrel/ ethinyl estradiol)

Avoid/Use Alternative


desogestrel (contraceptive) + desogestrel (contraceptive)

avoid combo: combo may incr. risk of thromboembolism, other adverse effects (additive effects, duplicate therapy)

ethinyl estradiol (contraceptive) + ethinyl estradiol (contraceptive)

avoid combo: combo may incr. risk of HTN, thromboembolism, endometrial hyperplasia, other adverse effects (additive effects, duplicate therapy)

Smiley face Smiley face Enskyce (desogestrel/ ethinyl estradiol) + Junel Fe 24 (norethindrone/ ethinyl estradiol)

Avoid/Use Alternative


desogestrel (contraceptive) + norethindrone (contraceptive)

avoid combo: combo may incr. risk of thromboembolism, other adverse effects (additive effects, duplicate therapy)

ethinyl estradiol (contraceptive) + ethinyl estradiol (contraceptive)

avoid combo: combo may incr. risk of HTN, thromboembolism, endometrial hyperplasia, other adverse effects (additive effects, duplicate therapy)

Smiley face Smiley face Isibloom (desogestrel/ ethinyl estradiol) + Junel Fe 24 (norethindrone/ ethinyl estradiol)

Avoid/Use Alternative


desogestrel (contraceptive) + norethindrone (contraceptive)

avoid combo: combo may incr. risk of thromboembolism, other adverse effects (additive effects, duplicate therapy)

ethinyl estradiol (contraceptive) + ethinyl estradiol (contraceptive)

avoid combo: combo may incr. risk of HTN, thromboembolism, endometrial hyperplasia, other adverse effects (additive effects, duplicate therapy)

Monitor/Modify Tx

Smiley face Smiley face Enskyce (desogestrel/ ethinyl estradiol) + ibuprofen/famotidine (generic)

Monitor/Modify Tx


desogestrel (contraceptive) + ibuprofen

monitor thrombosis s/sx, especially w/ concomitant estrogen use; use lowest effective ibuprofen dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

ethinyl estradiol (contraceptive) + ibuprofen

monitor BP, thrombosis s/sx; use lowest effective ibuprofen dose, shortest effective tx duration: combo may incr. risk of HTN, thromboembolism (additive effects)

Smiley face Smiley face Enskyce (desogestrel/ ethinyl estradiol) + Wellbutrin SR (bupropion hydrochloride)

Monitor/Modify Tx


ethinyl estradiol (contraceptive) + bupropion

monitor BP: combo may incr. risk of HTN (additive effects)

Smiley face Smiley face ibuprofen/famotidine (generic) + Isibloom (desogestrel/ ethinyl estradiol)

Monitor/Modify Tx


ibuprofen + desogestrel (contraceptive)

monitor thrombosis s/sx, especially w/ concomitant estrogen use; use lowest effective ibuprofen dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

ibuprofen + ethinyl estradiol (contraceptive)

monitor BP, thrombosis s/sx; use lowest effective ibuprofen dose, shortest effective tx duration: combo may incr. risk of HTN, thromboembolism (additive effects)

Smiley face Smiley face ibuprofen/famotidine (generic) + Junel Fe 24 (norethindrone/ ethinyl estradiol)

Monitor/Modify Tx


ibuprofen + ethinyl estradiol (contraceptive)

monitor BP, thrombosis s/sx; use lowest effective ibuprofen dose, shortest effective tx duration: combo may incr. risk of HTN, thromboembolism (additive effects)

ibuprofen + norethindrone (contraceptive)

monitor thrombosis s/sx, especially w/ concomitant estrogen use; use lowest effective ibuprofen dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

Smiley face Smiley face ibuprofen/famotidine (generic) + Wellbutrin SR (bupropion hydrochloride)

Monitor/Modify Tx


ibuprofen + bupropion

monitor BP: combo may incr. risk of HTN (additive effects)

Smiley face Smiley face Isibloom (desogestrel/ ethinyl estradiol) + Wellbutrin SR (bupropion hydrochloride)

Monitor/Modify Tx


ethinyl estradiol (contraceptive) + bupropion

monitor BP: combo may incr. risk of HTN (additive effects)

Smiley face Smiley face Junel Fe 24 (norethindrone/ ethinyl estradiol) + Wellbutrin SR (bupropion hydrochloride)

Monitor/Modify Tx


ethinyl estradiol (contraceptive) + bupropion

monitor BP: combo may incr. risk of HTN (additive effects)

Additional Considerations

Smiley face Smiley face bupropion in Wellbutrin SR

caution advised with concomitant drugs if smoking cessation use; dose adjustments may be necessary; smoking cessation may alter pharmacokinetics or pharmacodynamics of certain drugs

add MAO inhibitor to Interaction Check if recent (14 days) use

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