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Interaction Check

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Selected Drugs Clear All

  • remove Alka-Seltzer Plus Maximum Strength Cough, Mucus & Congestion PowerMax Night
    acetaminophen/ doxylamine/ dextromethorphan/ phenylephrine
  • remove Dulcolax Stool Softener
    docusate sodium
  • remove foscarnet
    generic
  • remove Merzee
    norethindrone/ ethinyl estradiol
  • remove Tremfya
    guselkumab
  • remove Vizz
    aceclidine ophthalmic

multicheck MultiCheck Results - 3 Interactions

Smiley face Smiley face

Monitor/Modify Tx

Smiley face Smiley face Alka-Seltzer Plus Maximum Strength Cough, Mucus & Congestion PowerMax Night (acetaminophen/ doxylamine/ dextromethorphan/ phenylephrine) + Merzee (norethindrone/ ethinyl estradiol)

Monitor/Modify Tx


acetaminophen + ethinyl estradiol (contraceptive)

monitor thrombosis s/sx: combo may incr. ethinyl estradiol levels, risk of thromboembolism, other adverse effects (mechanism unknown)

phenylephrine + ethinyl estradiol (contraceptive)

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

Smiley face Smiley face Alka-Seltzer Plus Maximum Strength Cough, Mucus & Congestion PowerMax Night (acetaminophen/ doxylamine/ dextromethorphan/ phenylephrine) + Vizz (aceclidine ophthalmic)

Caution Advised


doxylamine + aceclidine ophthalmic

caution advised: combo may decr. aceclidine efficacy (antagonistic effects)

Additional Considerations

Smiley face Smiley face phenylephrine in Alka-Seltzer Plus Maximum Strength Cough, Mucus & Congestion PowerMax Night

add MAO inhibitor to Interaction Check if recent (14 days) use

Smiley face Smiley face dextromethorphan in Alka-Seltzer Plus Maximum Strength Cough, Mucus & Congestion PowerMax Night

add MAO inhibitor to Interaction Check if recent (14 days) use

Smiley face Smiley face guselkumab in Tremfya

caution advised with drugs metabolized by CYP450 enzymes, especially with narrow therapeutic index; chronic inflammatory conditions may alter metabolic enzyme formation; tx with immune modulators may reverse this effect, resulting in altered levels of concomitant drugs

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