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A 2025 Lancet Diabetes & Endocrinology Commission proposed redefining obesity by distinguishing “preclinical” from “clinical” obesity and de emphasizing BMI—an approach now critically appraised by the Endocrine Society. . .

This rare autosomal recessive immunodeficiency is marked by delayed umbilical cord separation, recurrent severe bacterial and fungal infections, impaired wound healing, and absence of pus formation. . .

A CRISPR-based, gene-editing investigational therapy eliminated vaso-occlusive crises in nearly all treated patients in a small clinical trial. . .

An animal sedative increasingly detected in illicit opioids is linked to overdose risk and a uniquely severe withdrawal syndrome not responsive to standard care. . .

Personalized “digital twin” heart model-guided ablation achieved high rates of arrhythmia control in a small study. . .

Adrenergic signaling has been increasingly implicated in tumor progression, raising interest in repurposing cardiovascular beta blockers as adjunct cancer therapies. . .

Epstein-Barr virus–positive infectious mononucleosis was associated with a higher risk of multiple sclerosis. . .

GLP 1 receptor agonists reduce cardiovascular risk in randomized trials, but how these benefits interact with lifestyle behaviors in real world patients with T2D has been less clear. . .

Higher mid-life vitamin D levels were associated with lower tau levels later in life, but not with reduced amyloid beta levels. Both are common Alzheimer’s disease biomarkers. . .