G6PD Deficiency

Special Note

[drug class]

Info: U.S. drugs with hemolysis risk in G6PD deficient individuals; High Risk = avoid in all variants, Medium Risk = normal therapeutic doses usually safe for common variants, Low Risk = low risk in all variants

high risk

[analgesics/antipyretics/salicylates]

aspirin, mesalamine

[anti-infectives]

chloramphenicol, ciprofloxacin, levofloxacin, moxifloxacin, nitrofurantoin, ofloxacin

[anti-malarials]

chloroquine, hydroxychloroquine, mefloquine, primaquine, tafenoquine

[anti-neoplastics]

dabrafenib, doxorubicin

[nitrates]

nitric oxide, nitroglycerin, nitroprusside

[sulfonamides/sulfones]

brinzolamide, dapsone, dorzolamide, glimepiride, glipizide, glyburide, sulfacetamide, sulfamethoxazole, sulfasalazine

[urate-lowering agents]

pegloticase, probenecid, rasburicase

[miscellaneous]

bupivacaine, dimercaprol, methylene blue, phenazopyridine, vitamin K3, vitamin K4

medium risk

[analgesics/antipyretics]

acetaminophen, ibuprofen

[anti-infectives]

isoniazid, pyrimethamine, streptomycin, sulfadiazine, trimethoprim

[anti-malarials]

proguanil, quinine

[anti-neoplastics]

epirubicin

[anti-parkinsonism agents]

levodopa, trihexyphenidyl

[cardiovasculars]

dopamine, procainamide, quinidine

[miscellaneous]

acetazolamide, arginine, colchicine, phenytoin, prilocaine, succimer, vitamin K1

low risk

[anti-infectives]

mafenide

[miscellaneous]

ascorbic acid, azathioprine, baclofen, diphenhydramine, pregabalin, sodium nitrite