Oral Contraceptive Pill (OCP) Hormonal Activity and Therapeutic Equivalence

Special Note

[L = low; M = medium; H = high; BDC = brand discontinued; NA = not available]

activity: endometrial -- progestational -- androgenic

monophasic OCP with 20 mcg EE (21-day)

[norethindrone/ethinyl estradiol 1 mg/20 mcg]

L--M/H--H: Aurovela 1/20, Gildess 1/20 (BDC), Junel 1/20, Larin 1/20, Loestrin 21 1/20, Microgestin 1/20, norethindrone/ethinyl estradiol

monophasic OCP with 20 mcg EE (28-day)

[drospirenone/ethinyl estradiol 3 mg/20 mcg]

M/H--H--antiandrogenic: Gianvi (BDC), Loryna, Nikki, Vestura, Yaz, Lo-Zumandimine, drospirenone/ethinyl estradiol

[drospirenone/ethinyl estradiol/levomefolate 3 mg/20 mcg/451 mcg]

M/H--H--antiandrogenic: Beyaz, Rajani (BDC), drospirenone/ethinyl estradiol/levomefolate

[levonorgestrel/ethinyl estradiol 0.09 mg/20 mcg]

NA--M/L--M/H: Amethyst, Dolishale, Lybrel (BDC), levonorgestrel/ethinyl estradiol

[levonorgestrel/ethinyl estradiol 0.1 mg/20 mcg]

L--M/L--M/H: Alesse (BDC), Aubra EQ, Aviane, Falmina, Larissia, Lutera, Orsythia (BDC), Vienva, levonorgestrel/ethinyl estradiol

L--M/L--M/H: Lessina, Sronyx, levonorgestrel/ethinyl estradiol

L--M/L--M/H: Balcoltra, Minzoya

L--M/L--M/H: Tyblume

[norethindrone/ethinyl estradiol 1 mg/20 mcg]

L--M/H--H: Aurovela Fe 1/20, Blisovi Fe 1/20, Gildess Fe 1/20 (BDC), Hailey Fe 1/20, Junel Fe 1/20, Larin Fe 1/20, Loestrin Fe 1/20, Microgestin Fe 1/20, Tarina Fe 1/20, norethindrone/ethinyl estradiol

M/L--H--H: Mibelas 24 Fe, Minastrin 24 Fe (BDC), norethindrone/ethinyl estradiol

M/L--H--H: Gemmily, Merzee, Taytulla, norethindrone/ethinyl estradiol

M/L--H--H: Aurovela 24 Fe, Blisovi 24 Fe, Hailey 24 Fe, Junel Fe 24, Larin 24 Fe, Loestrin 24 Fe (BDC), Lomedia 24 Fe (BDC), norethindrone/ethinyl estradiol

M/L--H--H: Femlyv (no therapeutic equivalent)

monophasic OCP with 25 mcg EE (28-day)

[norethindrone/ethinyl estradiol 0.8 mg/25 mcg]

M/L--M/L--M/H: Generess Fe (BDC), Kaitlib Fe, norethindrone/ethinyl estradiol

monophasic OCP with 30 mcg EE (21-day)

[norethindrone/ethinyl estradiol 1.5 mg/30 mcg]

L--H--H: Aurovela 1.5/30, Gildess 1.5/30 (BDC), Hailey 1.5/30, Junel 1.5/30, Larin 1.5/30, Loestrin 21 1.5/30, Microgestin 1.5/30, norethindrone/ethinyl estradiol

monophasic OCP with 30 mcg EE (28-day)

[desogestrel/ethinyl estradiol 0.15 mg/30 mcg]

M/H--H--M/L: Apri, Averi, Desogen (BDC), Emoquette (BDC), Enskyce, Isibloom, Ortho-Cept (BDC), Reclipsen, desogestrel/ethinyl estradiol

[drospirenone/ethinyl estradiol 3 mg/30 mcg]

M/H--H--antiandrogenic: Ocella, Syeda, Yasmin, Zarah, Zumandimine, drospirenone/ethinyl estradiol

[drospirenone/ethinyl estradiol/levomefolate 3 mg/30 mcg/451 mcg]

M/H--H--antiandrogenic: Safyral, Tydemy, drospirenone/ethinyl estradiol/levomefolate

[levonorgestrel/ethinyl estradiol 0.15 mg/30 mcg]

M/H--M/L--M/H: Altavera, Kurvelo, Levora, Marlissa, Portia, levonorgestrel/ethinyl estradiol

[norethindrone/ethinyl estradiol 1.5 mg/30 mcg]

L--H--H: Aurovela Fe 1.5/30, Blisovi Fe 1.5/30, Gildess Fe 1.5/30 (BDC), Hailey Fe 1.5/30, Junel Fe 1.5/30, Larin Fe 1.5/30, Loestrin Fe 1.5/30, Microgestin Fe 1.5/30, norethindrone/ethinyl estradiol

[norgestrel/ethinyl estradiol 0.3 mg/30 mcg]

H--M/L--M/H: Cryselle, Elinest, Lo/Ovral-28 (BDC), Low-Ogestrel, Turqoz

monophasic OCP with 30 mcg EE (91-day)

[levonorgestrel/ethinyl estradiol 0.15 mg/30 mcg]

M/H--M/H--H: Introvale, Jolessa, Quasense (BDC), Seasonale (BDC), Setlakin, levonorgestrel/ethinyl estradiol

monophasic OCP with 35 mcg EE (28-day)

[ethynodiol/ethinyl estradiol 1 mg/35 mcg]

L--H--M/L: Kelnor 1/35, Zovia 1/35E (BDC)

[norethindrone/ethinyl estradiol 0.4 mg/35 mcg]

H--L--L: Balziva, Briellyn, Gildagia (BDC), Ovcon 35 (BDC), Philith, Vyfemla, Zenchent (BDC)

H--L--L: Femcon Fe (BDC), Wymzya Fe, Zenchent Fe (BDC), Zeosa (BDC), norethindrone/ethinyl estradiol

[norethindrone/ethinyl estradiol 0.5 mg/35 mcg]

M/L--M/L--M/L: Brevicon (BDC), Modicon (BDC), Necon 0.5/35 (BDC), Nortrel 0.5/35, Wera

[norethindrone/ethinyl estradiol 1 mg/35 mcg]

M/H--M/H--M/H: Alyacen 1/35, Cyclafem 1/35 (BDC), Dasetta 1/35, Necon 1/35 (BDC), Norinyl 1/35 (BDC), Nortrel 1/35, Ortho-Novum 1/35 (BDC), Pirmella 1/35 (BDC)

[norgestimate/ethinyl estradiol 0.25 mg/35 mcg]

M/H--L--M/L: Estarylla, Femynor (BDC), Mili, Mono-Linyah, MonoNessa (BDC), Ortho-Cyclen (BDC), Previfem (BDC), Sprintec, norgestimate/ethinyl estradiol

monophasic OCP with 50 mcg EE (28-day)

[ethynodiol/ethinyl estradiol 1 mg/50 mcg]

M/H--H--M/L: Kelnor 1/50, Zovia 1/50E (BDC), ethynodiol/ethinyl estradiol

monophasic OCP with 14.2 mg estetrol (28-day)

[drospirenone/estetrol 3 mg/14.2 mg]

NA--NA--NA: Nextstellis (no therapeutic equivalent)

biphasic OCP with 10 mcg EE (28-day)

[norethindrone/ethinyl estradiol 1 mg/10 mcg, 0 mg/10 mcg]

L--H--H: Lo Loestrin Fe (no therapeutic equivalent)

biphasic OCP with 10-20 mcg EE (28-day)

[desogestrel/ethinyl estradiol 0.15 mg/20 mcg, 0 mg/10 mcg]

M/L--H--M/L: Azurette, Bekyree (BDC), Kariva, Kimidess (BDC), Pimtrea, Viorele, Volnea, desogestrel/ethinyl estradiol

biphasic OCP with 10-20 mcg EE (91-day)

[levonorgestrel/ethinyl estradiol 0.1 mg/20 mcg, 0 mg/10 mcg]

M/L--M/L--M/H: Amethia Lo (BDC), CamreseLo, LoSeasonique (BDC), levonorgestrel/ethinyl estradiol

biphasic OCP with 10-30 mcg EE (91-day)

[levonorgestrel/ethinyl estradiol 0.15 mg/30 mcg, 0 mg/10 mcg]

M/H--M/H--H: Amethia, Ashlyna, Camrese, Daysee, Jaimiess, Seasonique (BDC), Simpesse, levonorgestrel/ethinyl estradiol

triphasic OCP with 20-35 mcg EE (28-day)

[norethindrone/ethinyl estradiol 1 mg/20 mcg, 1 mg/30 mcg, 1 mg/35 mcg]

M/L--M/H--H: Estrostep Fe (BDC), Tilia Fe, TriLegest Fe

triphasic OCP with 25 mcg EE (28-day)

[desogestrel/ethinyl estradiol 0.1 mg/25 mcg, 0.125 mg/25 mcg, 0.15 mg/25 mcg]

H--M/H--L: Caziant (BDC), Cyclessa (BDC), Velivet

[norgestimate/ethinyl estradiol 0.18 mg/25 mcg, 0.215 mg/25 mcg, 0.25 mg/25 mcg]

H--L--L: Ortho Tri-Cyclen Lo (BDC), Tri-Lo-Estarylla, Tri-Lo-Sprintec, Tri-Lo-Marzia, Tri-Lo-Mili, Tri-VyLibra Lo, norgestimate/ethinyl estradiol

triphasic OCP with 30-40 mcg EE (28-day)

[levonorgestrel/ethinyl estradiol 0.05 mg/30 mcg, 0.075 mg/40 mcg, 0.125 mg/30 mcg]

M/H--M/L--M/H: Enpresse, Levonest, Myzilra (BDC), Trivora, levonorgestrel/ethinyl estradiol

triphasic OCP with 35 mcg EE (28-day)

[norethindrone/ethinyl estradiol 0.5 mg/35 mcg, 0.75 mg/35 mcg, 1 mg/35 mcg]

M/H--M/L--M/H: Alyacen 7/7/7, Cyclafem 7/7/7 (BDC), Dasetta 7/7/7, Necon 7/7/7 (BDC), Nortrel 7/7/7, Ortho-Novum 7/7/7 (BDC), Pirmella 7/7/7 (BDC)

[norethindrone/ethinyl estradiol 0.5 mg/35 mcg, 1 mg/35 mcg, 0.5 mg/35 mcg]

L--M/L--M/L: Aranelle, Leena, Tri-Norinyl (BDC)

[norgestimate/ethinyl estradiol 0.18 mg/35 mcg, 0.215 mg/35 mcg, 0.25 mg/35 mcg]

M/L--L--L: Ortho Tri-Cyclen (BDC), Tri-Estarylla, Tri Femynor (BDC), Tri-Linyah, Tri-Mili, TriNessa (BDC), Tri-Previfem (BDC), Tri-Sprintec, Tri-VyLibra, norgestimate/ethinyl estradiol

quadriphasic OCP with 1-3 mg estradiol valerate (28-day)

[estradiol valerate/dienogest 3 mg/0 mg, 2 mg/2 mg, 2 mg/3 mg, 1 mg/0 mg]

M/H--L--antiandrogenic: Natazia (no therapeutic equivalent)

quadriphasic OCP with 10-30 mcg EE (91-day)

[levonorgestrel/ethinyl estradiol 0.15 mg/20 mcg, 0.15 mg/25 mcg, 0.15 mg/30 mcg, 0 mg/10 mcg]

M/L--M/H--H: Fayosim (BDC), Quartette, Rivelsa, levonorgestrel/ethinyl estradiol

progestogen-only OCP (28-day)

[drospirenone 4 mg]

NA--H--antiandrogenic: Slynd (no therapeutic equivalent)

[norgestrel 0.075 mg]

NA--NA--NA: Opill

[norethindrone 0.35 mg]

L--L--L: Camila, Deblitane, Heather, Incassia, Nora-BE, Norlyda (BDC), Nor-QD (BDC), norethindrone

L--L--L: Emzahh, Errin, Jencycla, Jolivette (BDC), Ortho Micronor (BDC), Sharobel, norethindrone