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Tryngolza
olezarsen
Adult Dosing .
Dosage forms: INJ (auto-injector): 80 mg
Restricted Distribution in US
- [1-844-789-8744 or www.tryngolzahcp.com for more info]
familial chylomicronemia syndrome
- [80 mg SC qmo]
renal dosing
- [see below]
- eGFR >30: no adjustment; eGFR <30: not defined
- HD/PD: not defined
hepatic dosing
- [see below]
- mild impairment: no adjustment; moderate-severe impairment: not defined
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
Drug Interactions .
Overview
olezarsen
antisense oligonucleotide
-
None
No significant interactions known or found for this drug. Caution always advised with multiple medications.
Adverse Reactions .
Serious Reactions
- hypersensitivity rxn
Common Reactions
- injection site rxn
- Plt decr.
- arthralgia
Safety/Monitoring .
Monitoring Parameters
no routine tests recommended
Pregnancy/Lactation .
Pregnancy
Clinical Summary
weigh risk/benefit during pregnancy; no human data available; no known risk of fetal harm based on animal data at 20-21x MRHD
Lactation
Clinical Summary
weigh risk/benefit while breastfeeding; no human data available to assess risk of infant harm or effects on milk production
Pharmacology .
Metabolism: liver; CYP450: unknown
Excretion: urine (<1% unchanged); Half-life: 4wk
Subclass: Dyslipidemia: Apolipoprotein C-III (APOC3) Inhibitors ; Inherited Metabolic Disorders
Mechanism of Action
binds to apolipoprotein C-III (APOC3) mRNA, reducing APOC3 production and incr. triglyceride and VLDL clearance (ligand-conjugated antisense oligonucleotide)
Formulary .
No Formulary Selected
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