IDWeek 2024: Seven-day antibiotic regimen effective for bloodstream infections

A seven-day antibiotic regimen for hospitalized patients with bloodstream infections is as effective as a 14-day course, according to findings from a randomized clinical trial presented at IDWeek 2024.

The study included 3,608 hospitalized patients with bloodstream infections from 74 hospitals across seven countries who were randomized to receive either 7 or 14 days of antibiotics. Primary outcome was 90-day mortality.

Both treatment durations showed similar 90-day mortality and relapse rates, with consistent results across various clinical outcomes and patient subgroups. The primary outcome of 90-day mortality occurred in 14.5% of patients receiving 7 days of antibiotics and 16.1% of patients in the 14-day arm, for an absolute difference of –1.6% (95% CI, –4.0% to 0.8%).

Source:

IDWeek. (2024, October 16). Antibiotic Treatment Regimen for Bloodstream Infections Can Safely Be Cut by Half. https://www.idsociety.org/news--publications-new/articles/2024/antibiotic-treatment-regimen-for-bloodstream-infections-can-safely-be-cut-by-half/