Br J Ophthalmol
Serum lipid levels linked to glaucoma risk
Serum lipid profiles may play a role in glaucoma risk, suggesting the need for further research into lipid-focused treatments for glaucoma management.
Study details: This prospective cohort study analyzed data from 400,229 participants in the UK Biobank to investigate the associations between serum lipid levels (HDL-C, LDL-C, total cholesterol, and triglycerides) and glaucoma incidence over a mean follow-up period of 14.44 years.
Results: Higher HDL-C levels were associated with an increased risk of glaucoma (hazard ratio [HR], 1.05 per 1-SD increase, 95% confidence interval [CI], 1.02-1.08, p=0.001). Conversely, elevated levels of the following were associated with a reduced risk of glaucoma: LDL-C (HR 0.96, 95% CI 0.94-0.99, P=0.005), total cholesterol (HR 0.97, 95% CI 0.94-1.00, P=0.037), and triglycerides (HR 0.96, 95% CI 0.94-0.99, P=0.008). Genetic risk analysis supported these findings for HDL-C but not for other lipids.
Source:
Ma Y, et al. (2025, February 4). Br J Ophthalmol. Associations between serum lipids and glaucoma: a cohort study of 400 229 UK Biobank participants. https://pubmed.ncbi.nlm.nih.gov/39904580/