Endocrine Society

Use of semaglutide, tirzepatide, dulaglutide may boost testosterone in men

July 21, 2025

Use of drugs like semaglutide, tirzepatide, and dulaglutide was linked to an increased proportion of patients who achieved normal testosterone levels, in this EHR review of males with obesity or type 2 diabetes presented at the Endocrine Society’s 2025 annual meeting.

Study details. Researchers examined EHR records for 110 male adults with obesity or type 2 diabetes who were treated with semaglutide, tirzepatide, or dulaglutide; patients weren’t on testosterone or other hormone therapy. Free and total testosterone were measured prior to and during 18 months of treatment.

Results. Patients lost 10% of body weight. The proportion of patients with normal total and free testosterone levels increased from 53% to 77% over the course of the study.

Source:

(2025, July 14). Endocrine Society. Anti-obesity medications can normalize testosterone levels in men [Press release]. https://www.endocrine.org/news-and-advocacy/news-room/endo-annual-meeting/endo-2025-press-releases/portillo-canales-press-release