Wrist cooling device shows promise for hot flashes related to cancer, menopause

Study details: This double-blind, randomized crossover trial evaluated the efficacy of KÜLKUF, a wrist-mounted cooling device, in 27 participants experiencing ≥2 moderate-to-severe hot flashes daily. The cohort included 10 patients with breast cancer 12 with and prostate cancer, as well as 5 postmenopausal women. Each participant alternated between active and placebo devices over two-week periods, serving as their own control.

Results: Active wrist cooling reduced severe hot flash episodes by 46% (p<0.02) and total daily hot flashes by 18%. Subgroup analysis showed consistent reductions: 41% in breast cancer patients and 50% in both postmenopausal women and prostate cancer patients. No adverse events or tolerability issues were reported. Statistical significance was maintained after adjusting for age and underlying condition (p<0.01).

Clinical impact: Peripheral thermoregulatory modulation via wrist cooling offers a safe, non-pharmaceutical alternative for managing vasomotor symptoms in populations where hormone therapy is contraindicated. This approach may improve quality of life and treatment adherence in cancer survivors and postmenopausal women.

Source:

Ucar, N., et al. (2025, September 20). AACE Endocrinol Diabetes. Peripheral Thermoregulatory Modulation for Hot Flash Management: Efficacy of Novel Wrist Cooling Device in Cancer Treatment-Induced and Menopausal Vasomotor Symptoms. https://www.sciencedirect.com/science/article/pii/S3050915725001195