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Depacon
valproate sodium
Black Box Warnings .
Brand Discontinued in US
select or search generic name for alternatives
Contraindications / Cautions .
- Brand Discontinued in US
Drug Interactions .
Overview
valproic acid
GABA modulator
Interaction Characteristics:
- UGT1A4 substrate
- UGT1A9 substrate
- UGT2B7 substrate
- epoxide hydrolase inhibitor
- UGT1A9 inhibitor
- UGT2B7 inhibitor
- UGT2B15 inhibitor
- CYP1A2 inducer, weak
- UGT1A1 inducer
- affected by altered fat absorption
- antiepileptic agent
- antiplatelet effects
- binds to anion exchange resin/polymer
- CNS depression
- hyperammonemia
- myelosuppressive effects
Contraindicated
- amifampridine
- bupropion
- dalfampridine
Avoid/Use Alternative
- acoramidis
- butalbital
- cabotegravir
- chloramphenicol
- cladribine oral
- clonidine
- codeine
- deferiprone
- dolutegravir
- doxylamine
- enoxaparin
- ertapenem
- estradiol (contraceptive)
- ethanol (alcoholic beverage)
- ethanol injection
- ethinyl estradiol (contraceptive)
- fexinidazole
- fondaparinux
- ganciclovir
- ginkgo
- haloperidol
- hydrocodone
- imipenem
- isocarboxazid
- kava
- kratom
- letermovir
- lorazepam
- meropenem
- metaxalone
- metoclopramide
- midazolam
- oxybate
- phenelzine
- pivmecillinam
- primaquine
- promethazine
- radium Ra 223 dichloride
- ropeginterferon alfa-2b
- sacituzumab govitecan
- scopolamine
- thalidomide
- topiramate
- tradipitant
- tranylcypromine
- trimethobenzamide
- valganciclovir
- valproic acid
- zuranolone
Monitor/Modify Tx
- abemaciclib
- abrocitinib
- acalabrutinib
- acetaminophen
- ado-trastuzumab emtansine
- afamitresgene autoleucel
- afatinib
- albendazole
- aldesleukin
- alemtuzumab
- alfentanil
- allopurinol
- alpha-tocopherol (vitamin E)
- alprazolam
- alprostadil intracavernous
- alprostadil intravenous
- alteplase
- aminophylline
- amitriptyline
- anacaulase topical
- anagrelide
- anti-thymocyte globulin
- antithrombin
- apixaban
- argatroban
- arsenic trioxide
- asciminib
- asparaginase
- aspirin
- atidarsagene autotemcel
- auranofin
- avapritinib
- axicabtagene ciloleucel
- axitinib
- azacitidine
- azathioprine
- baclofen intrathecal
- balsalazide
- baricitinib
- belantamab mafodotin
- belinostat
- bendamustine
- benznidazole
- betibeglogene autotemcel
- bevacizumab
- bexarotene
- binimetinib
- bivalirudin
- blinatumomab
- bortezomib
- bosutinib
- brentuximab vedotin
- brexucabtagene autoleucel
- bromelain
- bromfenac ophthalmic
- buprenorphine
- busulfan
- butorphanol
- cabazitaxel
- cabozantinib
- caffeine citrate
- calaspargase
- cangrelor
- cannabidiol
- capecitabine
- caplacizumab
- carbamazepine
- carboplatin
- carfilzomib
- carglumic acid
- carmustine
- celecoxib
- chlorambucil
- chlordiazepoxide
- chlorpromazine
- cholestyramine
- cidofovir
- cilostazol
- ciltacabtagene autoleucel
- cisplatin
- citalopram
- cladribine injection
- clarithromycin
- clobazam
- clofarabine
- clonazepam
- clopidogrel
- clorazepate
- clozapine
- colchicine
- collagenase clostridium histolyticum
- copanlisib
- copper histidinate
- crizotinib
- cyclophosphamide
- cysteamine
- cytarabine
- dabigatran
- dacarbazine
- dactinomycin
- dalteparin
- danshen
- dapsone
- daratumumab
- daridorexant
- dasatinib
- daunorubicin
- decitabine
- deferasirox
- defibrotide
- desflurane
- desvenlafaxine
- deuruxolitinib
- dexmedetomidine
- dexmedetomidine injection
- dexrazoxane
- diazepam
- diclofenac
- diclofenac ophthalmic
- diclofenac topical
- diflunisal
- dihydrocodeine
- dimethyl fumarate
- dinutuximab
- diosmin
- dipyridamole
- diroximel fumarate
- docetaxel
- dostarlimab
- doxorubicin
- droperidol
- duloxetine
- duvelisib
- edoxaban
- eflornithine
- elivaldogene autotemcel
- elranatamab
- encorafenib
- enfortumab vedotin
- entrectinib
- epcoritamab
- epirubicin
- epoprostenol
- eptifibatide
- eribulin
- erlotinib
- erythromycin
- escitalopram
- esketamine
- estazolam
- estradiol (hormone replacement)
- estrogens, conjugated (hormone replacement)
- estrogens, esterified (hormone replacement)
- eszopiclone
- ethanol (in some formulations)
- ethinyl estradiol (hormone replacement)
- ethosuximide
- etodolac
- etomidate
- etoposide
- etuvetidigene autotemcel
- evening primrose oil
- everolimus
- exagamglogene autotemcel
- fam-trastuzumab deruxtecan
- fedratinib
- felbamate
- fenoprofen
- fentanyl
- fenugreek
- floxuridine
- flucytosine
- fludarabine
- fluorouracil
- fluoxetine
- fluphenazine
- flurazepam
- flurbiprofen
- flurbiprofen ophthalmic
- fluvoxamine
- foscarnet
- fosfomycin injection
- fosphenytoin
- fostamatinib
- fruquintinib
- gabapentin
- gabapentin enacarbil
- ganaxolone
- garlic
- gefitinib
- gemcitabine
- gemtuzumab ozogamicin
- givinostat
- glasdegib
- glofitamab
- glycerol phenylbutyrate
- heparin
- hydrocortisone
- hydromorphone
- hydroxychloroquine
- hydroxyurea
- hydroxyzine
- ibritumomab tiuxetan
- ibrutinib
- ibuprofen
- ibuprofen lysine
- icosapent ethyl
- idarubicin
- idecabtagene vicleucel
- idelalisib
- ifosfamide
- imatinib
- imetelstat
- indomethacin
- inotuzumab ozogamicin
- interferon beta 1a
- interferon beta 1b
- interferon gamma 1b
- irinotecan
- isatuximab
- isoflurane
- isoniazid
- ivosidenib
- ixabepilone
- ketamine
- ketoprofen
- ketorolac
- ketorolac ophthalmic
- lamotrigine
- leflunomide
- lemborexant
- lenalidomide
- lenvatinib
- levomilnacipran
- levorphanol
- levothyroxine
- lifileucel
- linezolid
- linvoseltamab
- liothyronine
- lisocabtagene maraleucel
- lomustine
- lonafarnib
- loncastuximab tesirine
- lopinavir/ritonavir
- lovotibeglogene autotemcel
- lurbinectedin
- lutetium Lu 177 dotatate
- lutetium Lu 177 vipivotide tetraxetan
- lymphocyte immune globulin, anti-thymocyte globulin
- magnesium salicylate
- meclofenamate
- mefenamic acid
- meloxicam
- melphalan
- meperidine
- mercaptopurine
- mesalamine
- mesalamine rectal
- methadone
- methohexital
- methotrexate
- methyl salicylate topical
- midostaurin
- milnacipran
- mirtazapine
- mitomycin
- mitotane
- mitoxantrone
- mogamulizumab
- momelotinib
- monomethyl fumarate
- morphine
- mosunetuzumab
- mycophenolate mofetil
- mycophenolic acid
- nabumetone
- nalbuphine
- naproxen
- nattokinase
- nelarabine
- nelfinavir
- nepafenac ophthalmic
- nevirapine
- niacin (vitamin B3)
- nilotinib
- nintedanib
- niraparib
- nortriptyline
- nusinersen
- obecabtagene autoleucel
- obinutuzumab
- ofatumumab
- olanzapine
- olaparib
- oliceridine
- olsalazine
- omega-3-acid
- opicapone
- opium
- oxaliplatin
- oxaprozin
- oxazepam
- oxybutynin
- oxycodone
- oxymorphone
- paclitaxel
- pacritinib
- palbociclib
- paroxetine
- pazopanib
- pegaspargase
- peginterferon alfa 2a
- peginterferon beta 1a
- pemetrexed
- penicillamine
- penicillin G
- pentamidine
- pentazocine
- pentobarbital
- pentosan polysulfate sodium
- pentostatin
- pentoxifylline
- perphenazine
- phenobarbital
- phenytoin
- piperacillin
- piroxicam
- pirtobrutinib
- plasminogen, human
- polatuzumab vedotin
- pomalidomide
- ponatinib
- porfimer
- pralatrexate
- pralsetinib
- prasugrel
- pregabalin
- primidone
- procarbazine
- proguanil
- propofol
- pyrimethamine
- quazepam
- quizartinib
- ramucirumab
- ranibizumab
- regorafenib
- remibrutinib
- remifentanil
- remimazolam
- resveratrol
- reteplase
- revakinagene taroretcel
- ribavirin
- ribociclib
- rifabutin
- rifampin
- ritonavir
- rituximab
- rivaroxaban
- romidepsin
- rucaparib
- rufinamide
- ruxolitinib
- ruxolitinib topical
- salsalate
- sapropterin
- sarilumab
- satralizumab
- saw palmetto
- selinexor
- selpercatinib
- selumetinib
- sepiapterin
- sertraline
- sevoflurane
- sirolimus
- sirolimus albumin-bound
- sodium phenylacetate
- sodium phenylbutyrate
- sorafenib
- sotatercept
- stiripentol
- streptozocin
- succimer
- sufentanil
- sulfasalazine
- sulindac
- sunitinib
- suvorexant
- tafasitamab
- tagraxofusp
- talazoparib
- talquetamab
- tapentadol
- tarlatamab
- tazemetostat
- teclistamab
- telmisartan
- temazepam
- temozolomide
- temsirolimus
- tenecteplase
- teplizumab
- teriflunomide
- theophylline
- thioguanine
- thioridazine
- thiotepa
- thiothixene
- thyroid
- ticagrelor
- tipranavir
- tirofiban
- tisagenlecleucel
- tisotumab vedotin
- tivozanib
- tocilizumab
- tofacitinib
- tolmetin
- topotecan
- tovorafenib
- trabectedin
- tramadol
- trametinib
- trastuzumab
- trazodone
- treosulfan
- treprostinil
- triazolam
- trifluridine
- trimethoprim
- upadacitinib
- vadadustat
- vancomycin
- vandetanib
- venetoclax
- venlafaxine
- vilazodone
- vinblastine
- vincristine
- vinorelbine
- vinpocetine
- vorapaxar
- vorinostat
- vortioxetine
- warfarin
- willow bark
- zaleplon
- zanubrutinib
- ziconotide
- zidovudine
- ziv-aflibercept
- zolpidem
Caution Advised
- 5-HTP
- acyclovir
- almotriptan
- amantadine
- amoxapine
- amoxicillin
- amphetamine
- ampicillin
- apalutamide
- apomorphine
- apraclonidine ophthalmic
- aripiprazole bimonthly injection
- aripiprazole lauroxil
- aripiprazole monthly injection
- aripiprazole oral
- artesunate
- asenapine
- baclofen
- bazedoxifene
- benzphetamine
- betamethasone
- bictegravir
- brexpiprazole
- brimonidine ophthalmic
- brimonidine topical
- brivaracetam
- bromocriptine
- brompheniramine
- buspirone
- cannabis
- carbinoxamine
- cariprazine
- carisoprodol
- cefazolin
- cefepime
- cefiderocol
- ceftaroline
- ceftazidime
- ceftobiprole
- cenobamate
- cetirizine
- chamomile, German
- chlophedianol
- chlorcyclizine
- chloroquine
- chlorpheniramine
- chlorzoxazone
- ciprofloxacin
- cisatracurium
- clemastine
- clomipramine
- cocaine
- cortisone
- cyclobenzaprine
- cycloserine
- cyclosporine
- cyproheptadine
- dantrolene
- darbepoetin alfa
- darifenacin
- darolutamide
- deflazacort
- delafloxacin
- desipramine
- deutetrabenazine
- dexamethasone
- dexbrompheniramine
- dexchlorpheniramine
- dexmethylphenidate
- dextroamphetamine
- dichlorphenamide
- dicloxacillin
- diethylpropion
- difelikefalin
- difenoxin
- dimenhydrinate
- diphenhydramine
- diphenoxylate
- domperidone
- donepezil
- doxepin
- doxepin topical
- dronabinol
- efavirenz
- eletriptan
- elinzanetant
- entacapone
- enzalutamide
- ephedra
- epoetin alfa
- eslicarbazepine acetate
- fenfluramine
- fesoterodine
- flibanserin
- foslevodopa
- frovatriptan
- galantamine
- glycopyrrolate
- goserelin
- guanfacine
- histrelin
- hyoscyamine
- iloperidone
- imipramine
- iohexol
- iopamidol
- lacosamide
- lenacapavir
- leuprolide
- levetiracetam
- levocarnitine
- levocetirizine
- levodopa
- levofloxacin
- lidocaine
- lidocaine topical
- lisdexamfetamine
- lithium
- lofexidine
- lorlatinib
- loxapine
- lumateperone
- lurasidone
- magnesium citrate
- meclizine
- mefloquine
- melatonin
- meprobamate
- methamphetamine
- methocarbamol
- methoxy polyethylene glycol-epoetin beta
- methsuximide
- methyldopa
- metronidazole
- metyrapone
- metyrosine
- mexiletine
- milsaperidone
- molindone
- moxifloxacin
- nafarelin nasal
- nafcillin
- naltrexone
- naratriptan
- nefazodone
- ofloxacin
- orphenadrine
- oxacillin
- oxcarbazepine
- paliperidone
- passion flower
- penicillin V
- perampanel
- phendimetrazine
- pheniramine
- phentermine
- pimozide
- polyethylene glycol
- polyethylene glycol/electrolytes
- pramipexole
- prochlorperazine
- protriptyline
- pyridostigmine
- pyrilamine
- quetiapine
- quinine
- raltegravir
- ramelteon
- rasagiline
- regadenoson
- repotrectinib
- risperidone
- rivastigmine
- rizatriptan
- roflumilast
- ropinirole
- rotigotine transdermal
- safinamide
- selegiline
- selegiline transdermal
- silodosin
- sodium picosulfate
- solifenacin
- sulfate bowel prep
- sumatriptan
- tacrolimus
- tasimelteon
- terbutaline
- tetrabenazine
- tiagabine
- tinidazole
- tizanidine
- tolcapone
- tolterodine
- tranexamic acid
- triamcinolone
- trifluoperazine
- trihexyphenidyl
- trimipramine
- triprolidine
- triptorelin
- trospium
- valacyclovir
- valbenazine
- valerian
- varenicline
- vigabatrin
- viloxazine
- vorasidenib
- ziprasidone
- zolmitriptan
- zonisamide
Adverse Reactions .
Serious Reactions
- Brand Discontinued in US
Common Reactions
- Brand Discontinued in US
Safety/Monitoring .
Brand Discontinued in US
Look/Sound-Alike Drug Names
Depacon confused with: Decadron
Formulary .
No Formulary Selected
Manufacturer/Pricing .
Manufacturer: AbbVie Inc.
DEA/FDA: Discontinued
Retail Price
This information is currently not available for this drug.
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