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Xaciato
clindamycin vaginal
Adult Dosing .
Dosage forms: GEL (2%): 100 mg per applicatorful
bacterial vaginosis
- [1 applicatorful PV x1]
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic
- [not defined]
Peds Dosing .
- Dosage forms: GEL (2%): 100 mg per applicatorful
bacterial vaginosis
- [12 yo and older]
- Dose: 1 applicatorful PV x1
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- hypersensitivity to lincosamides
- avoid: polyurethane condom use during tx and x7 days after D/C
- caution: inflammatory bowel dz
Drug Interactions .
Overview
clindamycin vaginal
lincosamide vaginal
- alters GI flora
Avoid/Use Alternative
- fecal microbiota, live
- methotrexate
- progesterone vaginal (hormone replacement)
Caution Advised
- lactulose
Adverse Reactions .
Serious Reactions
- hypersensitivity rxn
- drug rxn w/ eosinophilia and systemic sx
- Stevens-Johnson syndrome
- acute generalized exanthematous pustulosis
- C. difficile-assoc. diarrhea
Common Reactions
- vulvovaginal irritation
- candidiasis, vulvovaginal
Safety/Monitoring .
Monitoring Parameters
no routine tests recommended
Look/Sound-Alike Drug Names
clindamycin confused with: clarithromycin; Clinoril; gentamicin; vancomycin
Pregnancy/Lactation .
Pregnancy
Clinical Summary
may use during pregnancy; no human data available, though risk of fetal harm not expected based on low systemic absorption and limited human data w/ other vaginal clindamycin forms
Lactation
Clinical Summary
may use while breastfeeding; no human data available, though risk of infant harm not expected based on low maternal systemic absorption; no human data available to assess effects on milk production
Pharmacology .
Metabolism: liver; CYP450: unknown; Info: active metabolites; low systemic absorption
Excretion: urine, feces; Half-life: 20h
Subclass: Antibacterials, Vaginal
Mechanism of Action
binds to 50S ribosomal subunit, inhibiting protein synthesis (lincosamide)
Formulary .
No Formulary Selected
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