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Nextstellis
drospirenone/ estetrol
Black Box Warnings .
Smoking and Cardiovascular Events
cigarette smoking incr. risk of serious cardiovascular events from combined hormonal contraceptive use; incr. risk w/ age (particularly for pts >35 yo) and w/ number of cigarettes smoked; contraindicated in smokers >35 yo
Adult Dosing .
Dosage forms: monophasic pack
Special Note
- [monophasic pack components]
- Info: 28-day pack contains drospirenone/estetrol 3 mg/14.2 mg tab x24, then inert tab x4
- [additional info]
- Info: see Oral Contraceptive Pill (OCP) Hormonal Activity and Therapeutic Equivalence table
contraception
- [1 tab PO qd]
- Start: day 1 of menstrual cycle, day 8 after complete 1st trimester abortion or miscarriage, or >4wk after 2nd trimester abortion or miscarriage; Info: for pts switching from another contraceptive method, refer to pkg insert; D/C >4wk before, restart >2wk after major surgery if VTE risk; restart >4wk postpartum or >6wk postpartum if breastfeeding
renal dosing
- [see below]
- renal impairment: contraindicated
- HD/PD: contraindicated
hepatic dosing
- [see below]
- hepatic impairment: contraindicated
Peds Dosing .
- Dosage forms: monophasic pack
Special Note
- [monophasic pack components]
- Info: 28-day pack contains drospirenone/estetrol 3 mg/14.2 mg tab x24, then inert tab x4
- [additional info]
- Info: see Oral Contraceptive Pill (OCP) Hormonal Activity and Therapeutic Equivalence table
contraception
- [postmenarchal pts]
- Dose: 1 tab PO qd; Start: day 1 of menstrual cycle, day 8 after complete 1st trimester abortion or miscarriage, or >4wk after 2nd trimester abortion or miscarriage; Info: for pts switching from another contraceptive method, refer to pkg insert; D/C >4wk before, restart >2wk after major surgery if VTE risk; restart >4wk postpartum or >6wk postpartum if breastfeeding
renal dosing
- [see below]
- renal impairment: contraindicated
- HD/PD: contraindicated
hepatic dosing
- [see below]
- hepatic impairment: contraindicated