Casgevy

Adult Dosing .

Dosage forms:  INJ

Restricted Distribution in US

[1-877-634-8789 or www.casgevy.com for more info]

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses, premeds, prophylactic regimens, and dosing

sickle cell disease

[3 x10^6 CD34+ cells/kg/dose IV x1]

Start: between 48h and 7 days after myeloablative conditioning with busulfan; Info: for patients with recurrent vaso-occlusive crises; maintain HgbS <30%, Hgb <11.1 for at least 8wk before mobilization until myeloablative conditioning; do not start myeloablative conditioning until confirming exagamglogene autotemcel infusion bag(s) at tx facility and back-up collection of CD34+ cells available

beta-thalassemia, transfusion-dependent

[3 x10^6 CD34+ cells/kg/dose IV x1]

Start: between 48h and 7 days after myeloablative conditioning with busulfan; Info: maintain Hgb >11 before mobilization and x60 days before myeloablative conditioning; do not start myeloablative conditioning until confirming exagamglogene autotemcel infusion bag(s) at tx facility and back-up collection of CD34+ cells available

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  INJ

Restricted Distribution in US

[1-877-634-8789 or www.casgevy.com for more info]

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses, premeds, prophylactic regimens, and dosing

sickle cell disease

[12 yo and older]

Dose: 3 x10^6 CD34+ cells/kg/dose IV x1;Start: between 48h and 7 days after myeloablative conditioning with busulfan; Info: for patients with recurrent vaso-occlusive crises; maintain HgbS <30%, Hgb <11.1 for at least 8wk before mobilization until myeloablative conditioning; do not start myeloablative conditioning until confirming exagamglogene autotemcel infusion bag(s) at tx facility and back-up collection of CD34+ cells available

beta-thalassemia, transfusion-dependent

[12 yo and older]

Dose: 3 x10^6 CD34+ cells/kg/dose IV x1; Start: between 48h and 7 days after myeloablative conditioning with busulfan; Info: maintain Hgb >11 before mobilization and x60 days before myeloablative conditioning; do not start myeloablative conditioning until confirming exagamglogene autotemcel infusion bag(s) at tx facility and back-up collection of CD34+ cells available

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]