Select a medication above to begin.
Sporanox
itraconazole
Black Box Warnings .
CHF
should not use in onychomycosis patients if ventricular dysfunction such as CHF or CHF history; negative inotropic effects; D/C if CHF signs/symptoms occur
Drug Interactions
coadministration is contraindicated with methadone, disopyramide, dofetilide, dronedarone, quinidine, isavuconazole, dihydroergotamine, ergotamine, methylergonovine, irinotecan, lurasidone, oral midazolam, pimozide, triazolam, felodipine, nisoldipine, ivabradine, ranolazine, eplerenone, cisapride, naloxegol, lomitapide, lovastatin, simvastatin, avanafil, ticagrelor, finerenone, voclosporin, and, in subjects with varying degrees of renal or hepatic impairment, colchicine, fesoterodine, solifenacin; eliglustat coadministration contraindicated in poor or intermediate CYP2D6 metabolizers and in patients taking strong or moderate CYP2D6 inhibitors; venetoclax coadministration contraindicated in patients with CLL/SLL during venetoclax dose initiation and ramp-up phase; elevated plasma concentrations of these drugs may occur, leading to increased or prolonged pharmacologic effects and/or adverse reactions including for some drugs QT prolongation and ventricular tachyarrhythmias including torsades de pointes, a potentially fatal arrhythmia
Adult Dosing .
Dosage forms: CAP: 100 mg; SOLUTION: 10 mg per mL
Special Note
- [equivalency or interchangeability info]
- Info: not interchangeable with itraconazole 65 mg caps; do not substitute on a mg to mg basis
infections, fungal
- [200 mg cap PO qd-bid]
- Start: 200 mg cap PO tid x3 days for life-threatening infections; Max: 600 mg/day; Info: dose, duration vary by indication; divide dose bid if >200 mg/day; give caps with food
onychomycosis, fingernails
- [200 mg cap PO bid x7 days, off x21 days]
- Info: for immunocompetent patients; give x2 courses (8wk total); confirm diagnosis prior to tx; give caps with food
onychomycosis, toenails
- [200 mg cap PO qd x12wk]
- Info: for immunocompetent patients; confirm diagnosis prior to tx; give caps with food
candidiasis, oropharyngeal
- [20 mL PO qd x1-2wk]
- Alt: 10 mL PO bid x2-4wk; Info: for fluconazole-refractory disease; swish and swallow; give oral solution without food
candidiasis, esophageal
- [20 mL PO qd x14-21 days]
- Info: for fluconazole-refractory disease; swish and swallow; give oral solution without food
blastomycosis
- [200 mg cap PO qd]
- Max: 400 mg/day; Info: for pulmonary and extrapulmonary disease; may incr. by 100 mg if no improvement; divide dose bid if >200 mg/day; give caps with food; start 200 mg PO tid x3 days if life-threatening infection, max 600 mg/day
histoplasmosis
- [200 mg cap PO qd]
- Max: 400 mg/day; Info: may incr. by 100 mg if no improvement; divide dose bid if >200 mg/day; give caps with food; start 200 mg PO tid x3 days if life-threatening infection, max 600 mg/day
aspergillosis, invasive
- [20 mL PO q12h]
- Alt: 200-400 mg cap PO qd; Info: for salvage tx; divide dose bid if >200 mg/day; oral solution preferred; give oral solution without food, caps with food; caps and oral solution not bioequivalent; oral solution with higher bioavailability; caution advised if switching between products
superficial mycoses (off-label)
- [100-200 mg cap PO qd-bid]
- Max: 600 mg/day; Info: dose, duration varies by indication; divide dose bid if >200 mg/day; give caps with food
coccidioidomycosis (off-label)
- [200 mg cap PO q12h]
- Info: give caps with food
meningitis, coccidioidal (off-label)
- [200 mg cap PO q12h]
- Info: continue for lifetime; give caps with food
sporotrichosis, cutaneous/lymphocutaneous (off-label)
- [200 mg PO qd]
- Info: may incr. to 200 mg PO bid; continue until 2-4wk after lesions resolved; oral solution preferred; give caps with food, oral solution without food; caps and oral solution not bioequivalent; oral solution with higher bioavailability; caution advised if switching between products
renal dosing
- [see below]
- CrCl <10: decr. usual dose by 50%
- HD: 100 mg q12-24h; no supplement after dialysis; PD: 100 mg q12-24h; no supplement
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised
Peds Dosing .
- Dosage forms: CAP: 100 mg; SOLUTION: 10 mg per mL
Special Note
- [equivalency or interchangeability info]
- Info: not interchangeable with itraconazole 65 mg caps; do not substitute on a mg to mg basis
infections, fungal (off-label)
- [5 mg/kg/day PO divided qd-bid]
- Max: 10 mg/kg/day or 600 mg/day; Alt: 100 mg PO qd; Info: dose, duration vary by indication; divide dose bid if >200 mg/day; give caps with food, oral solution without food; caps and oral solution not bioequivalent; oral solution with higher bioavailability; caution advised if switching between products
superficial mycoses (off-label)
- [5 mg/kg/day PO divided qd-bid]
- Max: 10 mg/kg/day or 600 mg/day; Alt: 100 mg PO qd; Info: dose, duration vary by indication; divide dose bid if >200 mg/day; give caps with food, oral solution without food; caps and oral solution not bioequivalent; oral solution with higher bioavailability; caution advised if switching between products
sporotrichosis, cutaneous/lymphocutaneous (off-label)
- [children]
- Dose: 6-10 mg/kg/day PO divided qd-bid; Max: 400 mg/day; Info: continue until 2-4wk after lesions resolved; oral solution preferred; give caps with food, oral solution without food; caps and oral solution not bioequivalent; oral solution with higher bioavailability; caution advised if switching between products
renal dosing
- [not defined]
- renal impairment: consider adult renal dosing for guidance
- HD/PD: consider adult renal dosing for guidance
hepatic dosing
- [not defined]
- hepatic impairment: consider adult hepatic dosing for guidance