Excedrin Migraine

Uses .

[ acetaminophen ]

analgesic for reducing pain; antipyretic for reducing fever

[ aspirin ]

salicylate for reducing pain/inflammation, fever

[ caffeine ]

methylxanthine stimulant for enhancing analgesia

Dosing .

adults

[ oral tablet ]

Dose: 2 tabs PO x1; Max: 2 tabs/24h; 4 g/day acetaminophen from all sources

renal considerations

[ acetaminophen; aspirin; caffeine ]

CrCl 10-89: consider alternatives, dose adjustment not possible w/ fixed-dose combo; CrCl <10: avoid use

HD: consider alternatives, dose adjustment not possible w/ fixed-dose combo; PD: avoid use

hepatic considerations

[ acetaminophen; aspirin; caffeine ]

hepatic impairment: consider alternatives, dose adjustment not possible w/ fixed-dose combo