prochlorperazine maleate

Adult Dosing .

Dosage forms:  TAB: 5 mg, 10 mg

nausea/vomiting, severe

[5-10 mg PO q6-8h]

Max: 10 mg/dose, 40 mg/day; Info: D/C if ANC <1000; consider D/C if unexplained decr. in WBC

anxiety, non-psychotic

[5 mg PO q6-8h]

Max: 20 mg/day, x12wk; Info: not drug of choice; D/C if ANC <1000; consider D/C if unexplained decr. in WBC

schizophrenia

[5-10 mg PO q6-8h]

Max: 150 mg/day; Info: may incr. 5-10 mg q2-3 days; D/C if ANC <1000; consider D/C if unexplained decr. in WBC

nausea/vomiting, migraine-associated (off-label)

[5-10 mg PO q6-8h prn]

Max: 40 mg/day; Info: D/C if ANC <1000; consider D/C if unexplained decr. in WBC

nausea/vomiting prevention, chemo-related (off-label)

[low-emetogenic parenteral chemo]

Dose: 10 mg PO x1 before chemo; Info: may repeat 10 mg PO qd for multi-day chemo; D/C if ANC <1000; consider D/C if unexplained decr. in WBC; search 'CINV' for epocrates Chemo-Induced Nausea & Vomiting in Adults decision tool

[oral chemo]

Dose: 10 mg PO x1 on day 1 before chemo, then 10 mg PO q6h prn; Max: 40 mg/day; Info: D/C if ANC <1000; consider D/C if unexplained decr. in WBC; search 'CINV' for epocrates Chemo-Induced Nausea & Vomiting in Adults decision tool

refractory nausea/vomiting, chemo-related (off-label)

[10 mg PO q6h]

Info: D/C if ANC <1000; consider D/C if unexplained decr. in WBC; search 'CINV' for epocrates Chemo-Induced Nausea & Vomiting in Adults decision tool

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  TAB: 5 mg, 10 mg

nausea/vomiting, severe

[2 yo and older, 9-14 kg]

Dose: 2.5 mg PO q12-24h; Max: 7.5 mg/day; Info: D/C if ANC <1000; consider D/C if unexplained decr. in WBC

[2 yo and older, 14-18 kg]

Dose: 2.5 mg PO q8-12h; Max: 10 mg/day; Info: D/C if ANC <1000; consider D/C if unexplained decr. in WBC

[2 yo and older, 18-39 kg]

Dose: 2.5 mg PO q8h; Max: 15 mg/day; Alt: 5 mg PO q12h; Info: D/C if ANC <1000; consider D/C if unexplained decr. in WBC

[2 yo and older, >39 kg]

Dose: 5 mg PO q6-8h; Max: 20 mg/day; Info: D/C if ANC <1000; consider D/C if unexplained decr. in WBC

schizophrenia

[2-5 yo]

Dose: 2.5-5 mg PO q6-8h; Start: 2.5 mg PO q8-12h; Max: 20 mg/day; Info: D/C if ANC <1000; consider D/C if unexplained decr. in WBC

[6-12 yo]

Dose: 2.5-5 mg PO q6-8h; Start: 2.5 mg PO q8-12h; Max: 25 mg/day; Info: D/C if ANC <1000; consider D/C if unexplained decr. in WBC

[>12 yo]

see Adult Dosing

nausea/vomiting, migraine-associated (off-label)

[2 yo and older, 9-14 kg]

Dose: 2.5 mg PO q12-24h prn; Max: 7.5 mg/day; Info: D/C if ANC <1000; consider D/C if unexplained decr. in WBC

[2 yo and older, 14-18 kg]

Dose: 2.5 mg PO q8-12h prn; Max: 10 mg/day; Info: D/C if ANC <1000; consider D/C if unexplained decr. in WBC

[2 yo and older, 18-39 kg]

Dose: 2.5 mg PO q8h prn; Max: 15 mg/day; Alt: 5 mg PO q12h prn; Info: D/C if ANC <1000; consider D/C if unexplained decr. in WBC

[2 yo and older, >39 kg]

Dose: 5 mg PO q6-8h prn; Max: 20 mg/day; Info: D/C if ANC <1000; consider D/C if unexplained decr. in WBC

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]