Zomacton

Adult Dosing .

Dosage forms:  INJ

growth hormone deficiency

[non weight-based dosing]

Dose: individualize dose SC qd; Start: 0.15-0.3 mg SC qd, may incr. dose by 0.1-0.2 mg/day q1-2 months; Info: adjust dose based on IGF-1 levels and sx

[weight-based dosing]

Dose: individualize dose SC qd; Start: 0.006 mg/kg/dose SC qd; Max: 0.0125 mg/kg/day; Info: not recommended for obese pts; adjust dose based on IGF-1 levels and sx

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  INJ

growth hormone deficiency

[0.18-0.3 mg/kg/wk SC divided equally 3-7x/wk]

Info: D/C when pt reaches satisfactory ht, epiphyses close, or no response

growth failure, Turner syndrome-assoc.

[up to 0.375 mg/kg/wk SC divided equally 3-7x/wk]

Info: D/C when pt reaches satisfactory ht, epiphyses close, or no response

idiopathic short stature

[up to 0.37 mg/kg/wk SC divided equally 3-7x/wk]

Info: D/C when pt reaches satisfactory ht, epiphyses close, or no response

growth failure, SHOX-assoc.

[0.35 mg/kg/wk SC divided equally 3-7x/wk]

Info: D/C when pt reaches satisfactory ht, epiphyses close, or no response

growth failure, SGA-assoc.

[up to 0.47 mg/kg/wk SC divided equally 3-7x/wk]

Info: consider larger start dose if HSDS < -3 or older pubertal pt; consider starting 0.033 mg/kg/day if <4 yo and HSDS between -2 and -3; consider gradual dose decr. if substantial growth during 1st few yr of tx; D/C when pt reaches satisfactory ht, epiphyses close, or no response

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]