Lonsurf

Adult Dosing .

Dosage forms:  TAB: 15 mg/6.14 mg, 20 mg/8.19 mg

Special Note

[dosing clarification]

Info: dosing based on trifluridine component

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments

metastatic colorectal CA, previously treated

[35 mg/m^2/dose trifluridine PO bid on days 1-5 and days 8-12 of 28-day cycle]

Max: 80 mg/dose trifluridine; Info: round dose to nearest 5 mg; use w/ bevacizumab or as monotherapy; give w/ food

metastatic gastric CA, previously treated

[35 mg/m^2/dose trifluridine PO bid on days 1-5 and days 8-12 of 28-day cycle]

Max: 80 mg/dose trifluridine; Info: round dose to nearest 5 mg; give w/ food

renal dosing

[adjust dose amount]

CrCl 15-29: 20 mg/m^2/dose trifluridine bid on days 1-5 and days 8-12 of 28-day cycle, max 50 mg/dose trifluridine; CrCl <15: not defined

HD/PD: not defined

hepatic dosing

[see below]

bilirubin >1.5x ULN: avoid use

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.