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Culturelle
Lacticaseibacillus rhamnosus
Entire Monograph
Reported Uses
- NOTE: see Herb & Supplement Effectiveness Rating Definitions table
- abdominal pain [Insufficient Evidence]
- ADHD [Insufficient Evidence]
- allergic rhinitis [Insufficient Evidence]
- aphthous ulcer (canker sores) [Insufficient Evidence]
- atopic dermatitis (eczema) [Possibly Effective]
- atopic dz prevention [Possibly Effective]
- bacterial vaginosis [Insufficient Evidence]
- bipolar disorder [Insufficient Evidence]
- C. difficile infection prevention [Insufficient Evidence]
- cancer [Insufficient Evidence]
- candidiasis, oropharyngeal [Insufficient Evidence]
- candidiasis, vulvovaginal [Insufficient Evidence]
- child development [Insufficient Evidence]
- cognitive decline, age-related [Insufficient Evidence]
- cognitive function [Insufficient Evidence]
- cognitive impairment [Insufficient Evidence]
- colic [Insufficient Evidence]
- common cold [Insufficient Evidence]
- constipation [Insufficient Evidence]
- COVID-19 [Insufficient Evidence]
- critical illness (trauma) [Possibly Ineffective]
- Crohn dz [Insufficient Evidence]
- cystic fibrosis [Insufficient Evidence]
- dental caries prevention [Insufficient Evidence]
- dental plaque [Insufficient Evidence]
- denture stomatitis [Insufficient Evidence]
- diabetes [Insufficient Evidence]
- diarrhea [Insufficient Evidence]
- diarrhea, antibiotic-assoc. [Possibly Effective]
- diarrhea, chemo-related [Insufficient Evidence]
- diarrhea, malnourishment-related [Insufficient Evidence]
- diarrhea, rotaviral [Insufficient Evidence]
- gingivitis [Insufficient Evidence]
- group B streptococcal colonization [Insufficient Evidence]
- H. pylori infection [Insufficient Evidence]
- HIV/AIDS [Insufficient Evidence]
- HTN [Insufficient Evidence]
- hypercholesterolemia [Insufficient Evidence]
- IBS [Insufficient Evidence]
- lactose intolerance [Insufficient Evidence]
- malnutrition [Insufficient Evidence]
- metabolic syndrome [Insufficient Evidence]
- necrotizing enterocolitis [Insufficient Evidence]
- neurogenic bladder [Insufficient Evidence]
- nonalcoholic fatty liver dz [Insufficient Evidence]
- obesity [Insufficient Evidence]
- osteoarthritis [Insufficient Evidence]
- otitis media [Insufficient Evidence]
- peanut allergy [Possibly Ineffective]
- periodontitis [Insufficient Evidence]
- polycystic ovary syndrome [Insufficient Evidence]
- postop bowel function [Insufficient Evidence]
- postop infection [Insufficient Evidence]
- postop recovery [Insufficient Evidence]
- postpartum depression [Insufficient Evidence]
- pouchitis [Insufficient Evidence]
- respiratory infections [Insufficient Evidence]
- rheumatoid arthritis [Insufficient Evidence]
- short bowel syndrome [Insufficient Evidence]
- small intestinal bacterial overgrowth (SIBO) [Insufficient Evidence]
- stress [Insufficient Evidence]
- traveler's diarrhea prophylaxis [Insufficient Evidence]
- ulcerative colitis [Insufficient Evidence]
- UTI [Insufficient Evidence]
- ventilator-assoc. pneumonia prevention [Possibly Ineffective]
Reported Doses
Safety/efficacy may not be established; reported doses may be derived from limited or potentially inadequate studies w/ variable regimens, multi-ingredient products, or where concentration of active ingredients may vary widely
Special Note
- [formulation clarification]
- Info: uses and doses represent various probiotic-containing products; other Lacticaseibacillus species exist, but are not included; prior name was Lactobacillus rhamnosus, reclassified as Lacticaseibacillus; select proprietary products noted below
- [Culturelle products]
- Info: each capsule contains 10-20 billion CFUs L. rhamnosus GG; each chewable tablet contains 2.5-10 billion CFUs L. rhamnosus GG; each powder packet contains 2.5-5 billion CFUs L. rhamnosus GG; other multi-ingredient products exist
Effectiveness Ratings
- [see Herb & Supplement Effectiveness Rating Definitions table]
atopic dermatitis (eczema) tx
- [Possibly Effective]
- Dose: 30 billion CFUs/kg/day PO qd in infants (L. rhamnosus GG); Alt: 1 billion CFUs PO qd in pts <2 yo (L. rhamnosus LOCK 0900 25%, LOCK 0908 25% plus other probiotics); 20 billion CFUs PO bid in pts 1-13 yo (L. rhamnosus 19070-2 plus other probiotics); 10 billion CFUs PO qd in pts 1-12 yo (L. rhamnosus IDCC 3201); 3 billion CFUs PO qd (L. rhamnosus LRH020 plus other probiotics); 10 billion CFUs PO qd in pts 6-36 mo (L. rhamnosus GG)
atopic dermatitis (eczema) prevention
- [Possibly Effective]
- Dose: 6 billion CFUs PO qd (L. rhamnosus HN001); Alt: 2 billion CFUs PO qd (L. rhamnosus GG plus other probiotics); 2 billion CFUs PO qd (L. rhamnosus LPR plus other probiotics); 105 billion CFUs PO qd (L. rhamnosus GG plus other probiotics); Info: may start tx in pregnant pts at 32-36 wk gestation, then cont. until 2-6mo postpartum, then may cont. 2-6 billion CFUs PO qd in infants x2-24 mo after birth
atopic dz prevention
- [Possibly Effective]
- Dose: 10-20 billion CFUs PO qd (L. rhamnosus GG); Alt: 6 billion CFUs PO qd (L. rhamnosus HN001); Info: for infants w/ family hx of atopy; start tx in pregnant pts 2-5wk before delivery, then cont. in infants x3-36 mo after birth
bacterial vaginosis
- [Insufficient Evidence (PO route)]
- Dose: 4 billion CFUs/day PO divided qd-bid (L. rhamnosus GR-1 plus other probiotics); Info: used w/ metronidazole or tinidazole
- [Insufficient Evidence (PV route)]
- Dose: 200 million-2 billion CFUs PV qd x10 days (L. rhamnosus Lbp PB01-DSM 14870 plus other probiotics); Start: after clindamycin 2% vaginal cream x7 days
bipolar disorder
- [Insufficient Evidence]
- Dose: 100 million CFUs PO qd (L. rhamnosus GG plus other probiotics)
C. difficile infection prevention
- [Insufficient Evidence]
- Dose: 50-100 billion CFUs PO qd x5 days (L. rhamnosus CLR2 plus other probiotics); Info: used w/ antibiotics
candidiasis, vulvovaginal
- [Insufficient Evidence]
- Dose: 1 billion CFUs supp PV bid x7 days (L. rhamnosus GG); Info: used w/ conventional tx
cognitive decline, age-related
- [Insufficient Evidence]
- Dose: 10 billion CFUs PO qd (L. rhamnosus GG)
cognitive impairment
- [Insufficient Evidence]
- Dose: 10 billion CFUs PO qd (L. rhamnosus GG)
colic
- [Insufficient Evidence]
- Dose: 250 million CFUs PO qd (L. rhamnosus plus other probiotics); Alt: 5 billion CFUs PO qd (L. rhamnosus ATCC 53103); Info: for infants 2-12 wk
dental caries prevention, adult pts
- [Insufficient Evidence]
- Dose: 200 million CFUs PO qd (L. rhamnosus LB21); Info: used w/ or w/o fluoride
dental caries prevention, peds pts
- [Insufficient Evidence]
- Dose: 21-292 million CFUs PO qd (L. rhamnosus GG ATCC 53103); Info: for pts 1-6 yo
dental plaque, adult pts
- [Insufficient Evidence]
- Dose: 4 billion CFUs lozenge PO qd (L. rhamnosus GG ATCC 53103 plus other probiotics)
dental plaque, peds pts
- [Insufficient Evidence]
- Dose: 1.84 billion CFUs lozenge PO bid (L. rhamnosus GG plus other probiotics); Info: for pts 13-15 yo
diabetes mellitus, type 2
- [Insufficient Evidence]
- Dose: 111 billion CFUs PO qd (L. rhamnosus plus other probiotics)
diarrhea prevention, peds pts
- [Insufficient Evidence]
- Dose: 6 billion CFUs PO bid in pts 1-36 mo (L. rhamnosus GG); Alt: 37 billion CFUs PO qd in pts 6-24 mo (L. rhamnosus GG)
diarrhea, antibiotic-assoc., adult pts
- [Possibly Effective]
- Dose: 6-40 billion CFUs PO qd (L. rhamnosus GG); Alt: 100 billion CFUs PO qd (L. rhamnosus CLR2 plus other probiotics); 8 billion CFUs PO qd (L. rhamnosus R0011 plus other probiotics); 5 billion CFUs PO bid (L. rhamnosus NIZO 3689 plus other probiotics)
diarrhea, antibiotic-assoc., peds pts
- [Possibly Effective]
- Dose: 10-20 billion CFUs PO qd (L. rhamnosus GG); Alt: 20 billion CFUs PO bid (L. rhamnosus GG); Info: used w/ conventional tx
diarrhea, chemo-related
- [Insufficient Evidence]
- Dose: 10-20 billion CFUs/day PO divided bid (L. rhamnosus GG)
diarrhea, rotaviral, peds pts
- [Insufficient Evidence]
- Dose: 10-100 billion CFUs/125 g fermented milk PO bid (L. rhamnosus GG); Alt: 10-100 billion CFUs freeze-dried powder PO bid (L. rhamnosus GG); 3 billion CFUs PO bid (L. rhamnosus GG)
gingivitis, adult pts
- [Insufficient Evidence]
- Dose: 4 billion CFUs lozenge PO qd (L. rhamnosus GG ATCC 53103 plus other probiotics)
gingivitis, peds pts
- [Insufficient Evidence]
- Dose: 1.84 billion CFUs lozenge PO bid (L. rhamnosus GG plus other probiotics); Info: for pts 13-15 yo
group B streptococcal colonization
- [Insufficient Evidence]
- Dose: 4 billion CFUs PO qd (L. rhamnosus GR-1 plus other probiotics); Info: start tx in pregnant pt at 35-37 wk gestation, then cont. until delivery
H. pylori infection
- [Insufficient Evidence]
- Dose: 100 million-10 billion CFUs PO bid x14 days (L. rhamnosus GG plus other probiotics); Info: used w/ standard tx
IBS
- [Insufficient Evidence]
- Dose: 10 billion CFUs/day PO divided bid (L. rhamnosus plus other probiotics); Alt: 2.5 billion CFUs PO bid (L. rhamnosus LR110 plus other probiotics)
lactose intolerance
- [Insufficient Evidence]
- Dose: 5 billion CFUs PO qd (L. rhamnosus HN001 plus other probiotics)
nonalcoholic fatty liver dz, peds pts
- [Insufficient Evidence]
- Dose: 13 billion CFUs PO qd (L. rhamnosus DSMZ 21690 plus other probiotics)
obesity, adult pts
- [Insufficient Evidence]
- Dose: 162 million CFUs PO bid (L. rhamnosus)
obesity, peds pts
- [Insufficient Evidence]
- Dose: 20 billion CFUs PO qd (L. rhamnosus HN001 plus other probiotics); Info: for childhood prevention; start tx in pregnant pt from early gestation, then cont. until 6mo postpartum
polycystic ovary syndrome
- [Insufficient Evidence]
- Dose: 10 billion CFUs PO bid (L. rhamnosus UBLR-58 plus other probiotics); Start: 10 billion CFUs PO qd x2mo (L. rhamnosus UBLR-58 plus other probiotics)
postop bowel function
- [Insufficient Evidence]
- Dose: 6 million CFUs PO q12h (L. rhamnosus GG); Start: day of surgery
postop recovery
- [Insufficient Evidence]
- Dose: 6 million CFUs PO q12h (L. rhamnosus GG); Start: day of surgery
postpartum depression
- [Insufficient Evidence]
- Dose: 6 billion CFUs PO qd (L. rhamnosus HN001); Start: 14-16 wk gestation
respiratory infections, adult pts
- [Insufficient Evidence]
- Dose: 2 billion CFUs PO qd (L. rhamnosus GG plus other probiotics)
respiratory infections, peds pts
- [Insufficient Evidence]
- Dose: 130-260 million CFUs PO qd (L. rhamnosus GG); Info: for pts 1-6 yo
traveler's diarrhea prophylaxis
- [Insufficient Evidence]
- Dose: 2 billion CFUs PO qd (L. rhamnosus GG); Info: start tx 2 days before trip, cont. until end of trip
UTI prevention, adult pts
- [Insufficient Evidence (PO route)]
- Dose: 1 billion CFUs PO bid (L. rhamnosus GR-1 plus other probiotics)
- [Insufficient Evidence (PV route)]
- Dose: 1.6 billion CFUs/0.5 g supp PV 2x/wk x2wk, then qmo (L. rhamnosus plus other probiotics); Alt: 100 billion CFUs/mL PV 2x/wk (L. rhamnosus)
UTI prevention, peds pts
- [Insufficient Evidence]
- Dose: 25 mg/kg/dose PO bid (L. rhamnosus plus other probiotics); Max: 1000 mg/day; Info: for pts 4 mo-5 yo
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