pineapple enzyme

Reported Doses

Safety/efficacy may not be established; reported doses may be derived from limited or potentially inadequate studies with variable regimens, multi-ingredient products, or where concentration of active ingredients may vary widely

Effectiveness Ratings

[see Herb & Supplement Effectiveness Rating Definitions table]

arthralgia, aromatase inhibitor-induced

[Insufficient Evidence]

Dose: 20 mg PO qd

burn debridement

[Insufficient Evidence]

Dose: apply gel topically x1-2; Info: apply under occlusive dressing x4h; for use in adult and peds patients

chronic venous insufficiency

[Insufficient Evidence]

Dose: 50 mg PO bid x30 days, then 50 mg PO qd for up to 90 days in patients with mild-to-moderate symptoms; 100 mg PO bid x10 days, then 50 mg PO bid for up to 90 days in patients with severe symptoms

dental pain, postop

[Insufficient Evidence]

Dose: 160-1500 mg/day PO divided bid-qid x3-6 days; Alt: 200 mg PO x1 given 1h before surgery, then 200 mg PO q6h after surgery; 200 mg PO q6h x3 days starting on day of surgery, then 200 mg PO q12h x4 days

exercise-induced muscle soreness

[Insufficient Evidence]

Dose: 50 mg PO qid

knee pain

[Insufficient Evidence]

Dose: 200-400 mg PO qd

lymphedema

[Insufficient Evidence]

Dose: 100 mg PO qd

nephrolithiasis

[Insufficient Evidence]

Dose: 500 mg PO qd; Info: used with tamsulosin

ocular floaters

[Insufficient Evidence]

Dose: 190 mg PO qd-tid

osteoarthritis

[Insufficient Evidence]

Dose: 180 mg PO tid; Alt: 300 mg PO bid-tid; 250 mg PO bid

pain, postop

[Insufficient Evidence]

Dose: 50 mg PO qd; Alt: 200-350 mg PO q12h

periodontitis

[Insufficient Evidence]

Dose: 500 mg PO bid

peripheral neuropathy, chemo-induced

[Insufficient Evidence]

Dose: 20 mg PO qd

pityriasis lichenoides chronica

[Insufficient Evidence]

Dose: 40 mg PO tid x1mo, then 40 mg PO bid x1mo, then 40 mg PO qd x1mo

rhinosinusitis, adult patients

[Insufficient Evidence]

Dose: 40 mg PO qid x6 days; Alt: 200 mg PO qd-bid; Info: used with standard tx

rhinosinusitis, peds patients

[Insufficient Evidence]

Dose: 200 mg PO qd-bid; Info: for patients 12 yo and older; used with inhaled corticosteroids

swelling, postop

[Insufficient Evidence]

Dose: 180-350 mg PO bid; Info: used with or without standard tx

tendinopathy

[Insufficient Evidence]

Dose: 100 mg PO qd

wound healing

[Insufficient Evidence]

Dose: apply gel topically x4h up to 10x/day