Yutrepia

Adult Dosing .

Dosage forms:  DPI: 26.5 mcg per cap, 53 mcg per cap, 79.5 mcg per cap, 106 mcg per cap

Special Note

[strength clarification]

Info: 1 cap = 2 breaths; doses expressed as treprostinil amount

pulmonary arterial HTN

[treprostinil tx-naive pts]

Dose: 79.5-106 mcg inhaled qid; Start: 26.5 mcg inhaled 3-5x/day, may incr. by 26.5 mcg/dose qwk as tolerated; Max: 848 mcg/day

[conversion from treprostinil NEB 30 mcg (5 breaths) or less per dose]

Dose: 79.5-106 mcg inhaled qid; Start: 26.5 mcg inhaled 3-5x/day, may incr. by 26.5 mcg/dose qwk as tolerated; Max: 848 mcg/day

[conversion from treprostinil NEB 36-48 mcg (6-8 breaths) per dose]

Dose: 79.5-106 mcg inhaled qid; Start: 53 mcg inhaled 3-5x/day, may incr. by 26.5 mcg/dose qwk as tolerated; Max: 848 mcg/day

[conversion from treprostinil NEB 54-66 mcg (9-11 breaths) per dose]

Dose: 79.5-106 mcg inhaled qid; Start: 79.5 mcg inhaled 3-5x/day, may incr. by 26.5 mcg/dose qwk as tolerated; Max: 848 mcg/day

[conversion from treprostinil NEB 72-84 mcg (12-14 breaths) per dose]

Dose: 79.5-106 mcg inhaled qid; Start: 106 mcg inhaled 3-5x/day, may incr. by 26.5 mcg/dose qwk as tolerated; Max: 848 mcg/day

[conversion from treprostinil NEB 90-102 mcg (15-17 breaths) per dose]

Dose: 79.5-106 mcg inhaled qid; Start: 132.5 mcg inhaled 3-5x/day, may incr. by 26.5 mcg/dose qwk as tolerated; Max: 848 mcg/day

[conversion from treprostinil NEB 108 mcg (18 breaths) or more per dose]

Dose: 79.5-106 mcg inhaled qid; Start: 159 mcg inhaled 3-5x/day, may incr. by 26.5 mcg/dose qwk as tolerated; Max: 848 mcg/day

pulmonary HTN, interstitial lung dz-associated

[treprostinil tx-naive pts]

Dose: 79.5-106 mcg inhaled qid; Start: 26.5 mcg inhaled 3-5x/day, may incr. by 26.5 mcg/dose qwk as tolerated; Max: 848 mcg/day

[conversion from treprostinil NEB 30 mcg (5 breaths) or less per dose]

Dose: 79.5-106 mcg inhaled qid; Start: 26.5 mcg inhaled 3-5x/day, may incr. by 26.5 mcg/dose qwk as tolerated; Max: 848 mcg/day

[conversion from treprostinil NEB 36-48 mcg (6-8 breaths) per dose]

Dose: 79.5-106 mcg inhaled qid; Start: 53 mcg inhaled 3-5x/day, may incr. by 26.5 mcg/dose qwk as tolerated; Max: 848 mcg/day

[conversion from treprostinil NEB 54-66 mcg (9-11 breaths) per dose]

Dose: 79.5-106 mcg inhaled qid; Start: 79.5 mcg inhaled 3-5x/day, may incr. by 26.5 mcg/dose qwk as tolerated; Max: 848 mcg/day

[conversion from treprostinil NEB 72-84 mcg (12-14 breaths) per dose]

Dose: 79.5-106 mcg inhaled qid; Start: 106 mcg inhaled 3-5x/day, may incr. by 26.5 mcg/dose qwk as tolerated; Max: 848 mcg/day

[conversion from treprostinil NEB 90-102 mcg (15-17 breaths) per dose]

Dose: 79.5-106 mcg inhaled qid; Start: 132.5 mcg inhaled 3-5x/day, may incr. by 26.5 mcg/dose qwk as tolerated; Max: 848 mcg/day

[conversion from treprostinil NEB 108 mcg (18 breaths) or more per dose]

Dose: 79.5-106 mcg inhaled qid; Start: 159 mcg inhaled 3-5x/day, may incr. by 26.5 mcg/dose qwk as tolerated; Max: 848 mcg/day

renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised; Info: titrate slowly

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.